The purpose of this study was to test the utility of rapid expansion of supercritical solution (RESS) based cocrystallizations in inducing polymorph conversion and crystal disruption of chlorpropamide (CPD). CPD crystals were recrystallized by the RESS process utilizing supercritical carbon dioxide as the solvent. The supercritical region investigated for solute extraction ranged from 45 to 100°C and 2000 to 8000 psi. Solute extraction was made possible by utilizing a SFT-150.
Chandra Vemavarapu 1,2, Matthew J. Mollan 1and Thomas E. Needham2
1Pharmaceutical Sciences, Pfizer Global R&D, Ann Arbor, MI 48105 2Applied Pharmaceutical Sciences, University of Rhode Island, Kingston, RI 02881
AAPS PharmSciTech 2002; 3 (4) article 29 (http://www.aapspharmsci.org)