Consistent production of solid drug materials of desired particle and crystallographic morphologies under cGMP conditions is a frequent challenge to pharmaceutical researchers. The purpose of this article is therefore to provide the information and resources necessary for startup research involving particle formation using supercritical fluids. The importance of each stage of particle formation in tailoring the particle morphology is discussed in this article along with presenting various alternatives to perform these operations.
Chandra Vemavarapu a, b, ∗, Matthew J. Mollan a, Mayur Lodaya a, Thomas E. Needham b
a Pharmaceutical Sciences, Pfizer Global R&D, 2800 Plymouth Road, Ann Arbor, MI 48105, USA
b Applied Pharmaceutical Sciences, University of Rhode Island, Kingston, RI 02881
C. Vemavarapu et al. / International Journal of Pharmaceutics 292 (2005) 1–16