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AP-106 – Crystal Doping Aided by Rapid Expansion of Supercritical Solutions

The purpose of this study was to test the utility of rapid expansion of supercritical solution (RESS) based cocrystallizations in inducing polymorph conversion and crystal disruption of chlorpropamide (CPD). CPD crystals were recrystallized by the RESS process utilizing supercritical carbon … Continue reading →

Posted in Client Applications |

AP-107 – Solubilities of Substituted Phenols in Supercritical Fluid Carbon Dioxide

Substituted phenols are an important class of compounds having widespread use (germicides, disinfectants, ingredients in fuel, etc.) There is little information in the literature regarding the solubilities of phenols in SCF CO2. Accurate and precise solubility data for the compounds … Continue reading →

Posted in Client Applications |

AP-109 – Design and process aspects of laboratory scale SCF particle formation systems

Consistent production of solid drug materials of desired particle and crystallographic morphologies under cGMP conditions is a frequent challenge to pharmaceutical researchers.  The purpose of this article is therefore to provide the information and resources necessary for startup research involving … Continue reading →

Posted in Client Applications |

AP-110 – Low-Temperature Growth of Carbon Nanotubes from the Catalytic Decomposition of Carbon Tetrachloride

Of the variety of methods used to synthesize CNTs(carbon nanotubes), metalencapsulated dendrimers represent a particularly attractive catalyst for nanotube growth.  For such nanocomposite growth, our synthetic strategy has been to find a method to control the size and distribution of … Continue reading →

Posted in Client Applications |

AP-111 – Supercritical Fluid Facilitated Growth of Copper and Aluminum Oxide Nanoparticles

Within the last five years, there has been an explosion of research in supercritical fluids; more recent reports are now exploiting this medium for nanomaterials synthesis.  An important goal for undergraduate curricula should be the constant upgrading of content to … Continue reading →

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AP-112 – Supercritical Carbon Dioxide Extraction of Mitragyna Speciosa

Mitragyna speciosa is a narcotic plant but with specific medicinal importance. The main components of the leaves of M. speciosa are indole alkaloids. Previous scientific researches have shown that the alkaloidal extracts possess very potent anti-inflammatory, analgesic and opioid properties. … Continue reading →

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AP-113 – Evaluating biomass reactions with cosolvents/CO2 under subcritical and supercritical conditions

Cellulose and corn stover were subjected to a reaction with polar cosolvents (methanol and water)/CO2 at subcritical and supercritical conditions. Resulting products from a cellulose reaction at 300oC analyzed by GCMS consisted of a mixture of organic acids, sugars, and … Continue reading →

Posted in Client Applications |

AP-114 – Supercritical Carbon Dioxide Extraction of Catharanthus roseus

Catharantrus roseus is a well-known medicinal plant belonging to the family Apocynaceae. It is regarded as a rich source of pharmaceutically important indole alkaloids that are used as antitumor, hypotensive and antiarrhythmic agents.  Among the indole alkaloids, vinblastine and vincristine … Continue reading →

Posted in Client Applications |

AP-115 – Toward the Direct Synthesis of Alane: Hydrogenation Studies of
Aluminum in Supercritical Fluid Media

Aluminum hydride (alane) has received a great deal of interest in recent years due its possible use as a hydrogen storage material. Alane contains 10.1 weight % hydrogen which meets the 2015 target set by the DOE of 9 weight … Continue reading →

Posted in Client Applications |

AP-161 – Oil of Catnip by Supercritical Fluid Extraction

Dr. James Louey, Nathan Petersen, Dennis Salotti, Heather Shaeffer Chemistry Department, Sacred Heart University 5151 Park Avenue, Fairfield, CT 06432-1000 Dr. Kenneth James, Supercritical Fluid Technologies, Inc. One Innovation Way, Suite 303, Newark, Delaware 19711; Tel: 302-738-3420 x201; Fax: 302-738-4320; … Continue reading →

Posted in Technical Notes |

AP-162 – Application of Near Critical/Supercritical Solvent – Cleaning Processes

Jonathan A. Peters, The Pennsylvania State University, Applied Research Laboratory, P.O. Box 30, State College, PA 16804; Tel: 814-865-6373; Fax: 814-863-7842; E-mail: PNU@PSU.EDU Dr. Kenneth James, Supercritical Fluid Technologies, Inc. One Innovation Way, Suite 303, Newark, Delaware 19711; Tel: 302-738-3420 … Continue reading →

Posted in Technical Notes |

AP-163 – Advances in Determining the Solubility, Cloud Point, Swelling and Crystallization Properties of Materials in Supercritical Carbon Dioxide

Kenneth J. James, Ph.D.,* Supercritical Fluid Technologies, Inc., David Chesney, Ph.D., Michigan Technology University, Jennifer L. Lefler, GlaxoSmithKline Abstract Direct, visual observation of materials under supercritical conditions is an important first step in the development and refinement of supercritical fluid … Continue reading →

Posted in Technical Notes |

AP-164 – Assessing Technical Feasibility of Supercritical Extraction Processes of Naturally Occurring Materials Using Benchtop Laboratory Equipment

Kenneth J. James, Ph.D.,* Supercritical Fluid Technologies, Inc., Abstract The primary goal of a laboratory SFE and Phase Monitor unit testing is to assess technical feasibility of a potential supercritical fluid extraction application. Experimental work begins using a supercritical fluid … Continue reading →

Posted in Technical Notes |

AP-165 – Supercritical Fluid Technology: Green Chemistry for the 21st Century

Dr. James Louey, Chemistry Department, Sacred Heart University 5151 Park Avenue, Fairfield, CT 06432-1000 Dr. Kenneth James, Supercritical Fluid Technologies, Inc. One Innovation Way, Suite 303, Newark, Delaware 19711; Tel: 302-738-3420 x201; Fax: 302-738-4320; E-mail: ken.james@supercriticalfluids.com Abstract Currently, the U. … Continue reading →

Posted in Technical Notes |

AP-166 – Assessing Feasibility of Supercritical Reaction Processes Using Laboratory Equipment

Kenneth J. James, Ph.D.,* Supercritical Fluid Technologies, Inc. Kenneth R. Krewson, Supercritical Fluid Technologies, Inc Abstract The primary goal of laboratory supercritical fluid reaction unit testing is to assess technical feasibility of a potential supercritical fluid reaction application. Initial screening … Continue reading →

Posted in Technical Notes |

AP-167 – New Advances in Supercritical Fluid Extraction for the Quality Control/Quality Assurance Laboratory for Fat Analysis

Kenneth J. James, Ph.D.,* Supercritical Fluid Technologies, Inc. Kenneth R. Krewson, Supercritical Fluid Technologies, Inc., Abstract Supercritical fluid extraction has been gaining acceptance in quality control/quality assurance laboratories as a replacement technology for the traditional “organic solvent intensive” fat analysis … Continue reading →

Posted in Technical Notes |

AP-168 – Practical Applications of a “High Pressure” Chemical Reactor for Small Scale Laboratory Synthesis and Process Development

Kenneth J. James, Ph.D.,* Supercritical Fluid Technologies, Inc. Kenneth R. Krewson, Supercritical Fluid Technologies, Inc Abstract The goal of a high pressure laboratory reaction unit is to assess technical feasibility of pressurized reaction applications such as Catalytic Chemistry, Hydrolysis, Polymerization, … Continue reading →

Posted in Technical Notes |

Is it possible to use a Dewar type cylinder for the SFT-150, SFT-250, and NPX scale SFT systems?

Unfortunately, Dewar tanks have too low of a delivery pressure and temperature for our pumping systems in these units. Typically what a client will do when processing a lot of material on the SFT-150/SFT-250 scale unit in a lengthy “dynamic … Continue reading →

Posted in FAQ |

HPR-Micro Reactor™

The HPR-Micro Reactor™ is the ideal high pressure reactor for early, exploratory research….

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SFT – Flash 300

0.1 – 300.0 ml/min; 200 psi

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